SCHEMBL6436240

SCHEMBL6436240

NC(=O)C(c1ccc(F)c(F)c1)c1ccccn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.43
ALDH1A1 P00352 2/20 0.43
SLC6A3 Q01959 2/20 0.39
CYP3A4 P08684 2/20 0.39
LMNA P02545 2/20 0.39
KDM4E B2RXH2 1/20 0.39
ABCB11 O95342 1/20 0.39
ESR1 P03372 1/20 0.39
ADRA2A P08913 1/20 0.39
CYP2C9 P11712 1/20 0.39
TSHR P16473 1/20 0.39
PDE4A P27815 1/20 0.39
ADRA1A P35348 1/20 0.39
OPRK1 P41145 1/20 0.39
STAT6 P42226 1/20 0.39
HIF1A Q16665 1/20 0.39
GPR55 Q9Y2T6 1/20 0.39
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6431539 0.82 ALDH1A1 (0.44) CYP1A2ALDH1A1SLC6A3CYP3A4LMNA
SCHEMBL6431542 0.82 ALDH1A1 (0.44) CYP1A2ALDH1A1SLC6A3CYP3A4LMNA
SCHEMBL30637669 0.81 S1PR1 (0.43) ALDH1A1KDM4ECES2CES1HTT
SCHEMBL2134676 0.80 ALDH1A1 (0.47) CYP1A2ALDH1A1SLC6A3SLC6A2SLC6A4
SCHEMBL639563 0.80 ALDH1A1 (0.64) CYP1A2ALDH1A1SLC6A3CYP3A4LMNA
SCHEMBL7759530 0.80 ALDH1A1 (0.64) CYP1A2ALDH1A1SLC6A3CYP3A4LMNA
Hydrochloric Acid SCHEMBL27529639 0.79 ALDH1A1 (0.62) CYP1A2ALDH1A1SLC6A3CYP3A4LMNA
Hydrochloric Acid SCHEMBL4200885 0.79 ALDH1A1 (0.62) CYP1A2ALDH1A1SLC6A3CYP3A4LMNA
SCHEMBL29942045 0.78 HDAC4 (0.46) CYP1A2ALDH1A1CYP3A4CES2CES1
SCHEMBL19555119 0.77 ALDH1A1 (0.50) CYP1A2ALDH1A1SLC6A3CYP3A4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1224163-B1 USE OF CARBONYLAMINO DERIVATIVES AGAINST CNS DISORDERS HOFFMANN LA ROCHE (CH) 2005-03-30 EP disclosed
US-6548522-B1 N-substituted 2,2-diphenylacetamide or N-substituted 2-phenyl-2-pyridinylacetamide HOFFMANN-LA ROCHE INC. 2003-04-15 US disclosed
EP-1224163-A1 USE OF CARBONYLAMINO DERIVATIVES AGAINST CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2002-07-24 EP disclosed
WO-2001027070-A1 USE OF CARBONYLAMINO DERIVATIVES AGAINST CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2001-04-19 WO disclosed