Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 18/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.50 |
| ▸ | KLK1 | P06870 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 6/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432347 | 0.89 | F10 (0.61) | F10KLKB1KLK1F2 | |
| Iodide SCHEMBL6434334 | 0.87 | F10 (0.63) | F10KLKB1KLK1F2 | |
| SCHEMBL6432887 | 0.86 | F10 (0.54) | F10KLKB1KLK1F2RORC | |
| SCHEMBL6433702 | 0.86 | F10 (0.54) | F10KLKB1KLK1F2 | |
| SCHEMBL6438708 | 0.82 | F10 (0.66) | F10KLKB1KLK1F2RORC | |
| SCHEMBL6438689 | 0.81 | F10 (0.63) | F10F2 | |
| SCHEMBL6434144 | 0.81 | F10 (0.52) | F10KLKB1KLK1 | |
| SCHEMBL6433022 | 0.80 | F10 (0.65) | F10KLKB1KLK1F2 | |
| SCHEMBL6436601 | 0.80 | F10 (0.67) | F10F2 | |
| SCHEMBL6432749 | 0.80 | CCR2 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042287-B1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | AVENTIS PHARMA GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |