Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 12/20 | 0.62 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | RHEB | Q15382 | 2/20 | 0.46 |
| ▸ | CCR9 | P51686 | 2/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432935 | 0.87 | CCR2 (0.64) | CCR2FEN1CCR9GPR35 | |
| SCHEMBL6432960 | 0.86 | CCR2 (0.65) | CCR2FEN1CCR9GPR35 | |
| SCHEMBL6432566 | 0.85 | F10 (0.54) | CCR2PIK3R1PIK3CA | |
| SCHEMBL6433546 | 0.83 | CCR2 (0.67) | CCR2FEN1CCR9PIK3R1PIK3CA | |
| SCHEMBL4551188 | 0.82 | CCR2 (0.56) | CCR2RHEB | |
| SCHEMBL6433076 | 0.82 | CCR2 (0.77) | CCR2FEN1CCR9GPR35 | |
| SCHEMBL6432404 | 0.81 | CCR2 (0.57) | CCR2FEN1 | |
| SCHEMBL6436704 | 0.81 | CCR2 (0.78) | CCR2FEN1CCR9GPR35PIK3R1 | |
| SCHEMBL6436384 | 0.80 | F10 (0.54) | — | |
| Iodide SCHEMBL6434334 | 0.79 | F10 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042287-B1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | AVENTIS PHARMA GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |