Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 8/20 | 0.47 |
| ▸ | CCR2 | P41597 | 5/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | CLPP | Q16740 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6436700 | 0.94 | F10 (0.51) | F10CCR2ADRA1DF2KDM4E | |
| SCHEMBL6438711 | 0.80 | PIK3R1 (0.44) | F10CCR2KDM4EALDH1A1FEN1 | |
| SCHEMBL6433028 | 0.79 | PLA2G2A (0.44) | F10POLBKLKB1KLK1 | |
| SCHEMBL6435691 | 0.78 | PLA2G2A (0.44) | F10POLBFEN1KLKB1KLK1 | |
| Hydrochloric Acid SCHEMBL6434176 | 0.77 | F10 (0.56) | F10CCR2F2KLKB1 | |
| SCHEMBL6432965 | 0.77 | F10 (0.66) | F10CCR2ALDH1A1FEN1KLKB1 | |
| SCHEMBL6433063 | 0.76 | F10 (0.43) | F10CCR2ADRA1DPOLBFEN1 | |
| SCHEMBL6432971 | 0.75 | F10 (0.58) | F10CCR2ALDH1A1FEN1KLKB1 | |
| SCHEMBL6432583 | 0.73 | F10 (0.58) | F10CCR2ALDH1A1POLBFEN1 | |
| SCHEMBL6437062 | 0.72 | POLB (0.49) | F10CCR2F2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042287-B1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | AVENTIS PHARMA GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |