Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GPR3 | P46089 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721073 | 0.60 | — | — | |
| Naphthalene SCHEMBL17967480 | 0.60 | CYP2A6 (0.57) | KDM4EALDH1A1HSD17B10GLAHPGD | |
| Naphthalene SCHEMBL17394701 | 0.60 | CYP2A6 (0.57) | ALDH1A1HSD17B10LMNAHPGDSMN1; SMN2 | |
| SCHEMBL4558727 | 0.58 | KDM4E (0.67) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29495630 | 0.58 | KDM4E (1.00) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL37951 | 0.58 | KDM4E (0.67) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL14700976 | 0.56 | MEN1 (0.32) | KDM4ELMNAHTTSMN1; SMN2MAPT | |
| Naphthalene SCHEMBL1330659 | 0.53 | CYP2A6 (1.00) | ALDH1A1HSD17B10GLAHPGDATM | |
| Naphthalene SCHEMBL8613802 | 0.53 | CYP2A6 (1.00) | ALDH1A1HSD17B10GLAHPGDATM | |
| Naphthalene SCHEMBL1332240 | 0.53 | CYP2A6 (1.00) | ALDH1A1HSD17B10GLAHPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984930-B1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN INC (US) | 2005-04-06 | — | — | EP | disclosed |