Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | CCR1 | P32246 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.50 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050745 | 0.91 | CCR1 (0.68) | POLBCCR1ALDH1A1TSHR | |
| SCHEMBL11094731 | 0.88 | POLB (0.55) | POLBCCR1ALDH1A1HDAC3HDAC4 | |
| SCHEMBL11226541 | 0.88 | POLB (0.58) | POLBCCR1ALDH1A1HDAC3HDAC4 | |
| SCHEMBL6159618 | 0.82 | POLB (0.56) | POLBCCR1ALDH1A1HDAC3HDAC4 | |
| SCHEMBL7242918 | 0.82 | DRD4 (0.61) | POLBCCR1ALDH1A1TSHRC3AR1 | |
| SCHEMBL25464181 | 0.81 | GRM7 (0.73) | TSHRGRM7 | |
| SCHEMBL8225263 | 0.81 | GRM7 (0.73) | TSHRGRM7 | |
| SCHEMBL998303 | 0.81 | TSHR (0.50) | CCR1ALDH1A1TSHRMAPTGRM7 | |
| SCHEMBL25464184 | 0.81 | GRM7 (0.73) | TSHRGRM7 | |
| SCHEMBL25968891 | 0.81 | CES2 (0.52) | POLBCCR1TSHRMAPTGRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224163-B1 | USE OF CARBONYLAMINO DERIVATIVES AGAINST CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-03-30 | — | — | EP | disclosed |
| CN-1184964-C | Use of carbonylamino derivatives against CNS disorders | HOFFMANN LA ROCHE (CH) | 2005-01-19 | — | — | CN | disclosed |
| US-6548522-B1 | N-substituted 2,2-diphenylacetamide or N-substituted 2-phenyl-2-pyridinylacetamide | HOFFMANN-LA ROCHE INC. | 2003-04-15 | — | — | US | disclosed |
| EP-1224163-A1 | USE OF CARBONYLAMINO DERIVATIVES AGAINST CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027070-A1 | USE OF CARBONYLAMINO DERIVATIVES AGAINST CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-19 | — | — | WO | disclosed |