Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ABCC1 | P33527 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.58 |
| ▸ | PTPRC | P08575 | 1/20 | 0.58 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.58 |
| ▸ | PTPRB | P23467 | 1/20 | 0.58 |
| ▸ | PTPRE | P23469 | 1/20 | 0.58 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24104916 | 0.99 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL3125764 | 0.88 | ALDH1A1 (0.88) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL17816985 | 0.87 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL8288688 | 0.86 | ALDH1A1 (0.91) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL8288697 | 0.86 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL3646473 | 0.86 | KDM4E (0.76) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL17817432 | 0.85 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL3684643 | 0.85 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL8288672 | 0.85 | ALDH1A1 (0.93) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL3648831 | 0.84 | KDM4E (0.78) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492783-A1 | 4,5,6,7-TRETRAHYDROBENZO(B) THIOPHENE DERIVATIVES AND METHODS FOR MEDICAL INTERVENTION AGAINST MYCROBACTERIAL INFECTIONS | Axxima Pharmaceuticals AG (DE) | 2005-01-05 | — | — | EP | claimed |
| WO-2003084947-A1 | 4,5,6,7-TRETRAHYDROBENZO[B] THIOPHENE DERIVATIVES AND METHODS FOR MEDICAL INTERVENTION AGAINST MYCROBACTERIAL INFECTIONS | AXXIMA PHARMACEUTICALS AG (DE) | 2003-10-16 | — | — | WO | claimed |