Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.88 |
| ▸ | MEN1 | O00255 | 2/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.88 |
| ▸ | RAB9A | P51151 | 1/20 | 0.88 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.88 |
| ▸ | FLT3 | P36888 | 5/20 | 0.74 |
| ▸ | HPGD | P15428 | 5/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288697 | 0.99 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL8288672 | 0.97 | ALDH1A1 (0.93) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL8288688 | 0.96 | ALDH1A1 (0.91) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL5457782 | 0.96 | ALDH1A1 (0.95) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL4135422 | 0.94 | HPGD (0.83) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL5465217 | 0.91 | ALDH1A1 (0.81) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL6437345 | 0.88 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL24104916 | 0.86 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL8289669 | 0.86 | HPGD (0.76) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL5453467 | 0.85 | FLT3 (1.00) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696244-B2 | Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-13 | — | — | US | disclosed |
| US-20070265316-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-11-15 | — | — | US | disclosed |
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |
| WO-2004110352-A2 | COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265316-A1 | Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof | CFTR, SLC47A1, SLC47A2 | ALDH1A1 1218/4885SMN1; SMN2 3371/4885MEN1 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.