Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438867 | 1.00 | SIGMAR1 (0.53) | SIGMAR1CCR5SLC18A3KDM1AMAOB | |
| SCHEMBL6442345 | 0.93 | SIGMAR1 (0.48) | SIGMAR1CCR5SLC18A3BCHEACHE | |
| SCHEMBL6442347 | 0.93 | SIGMAR1 (0.48) | SIGMAR1CCR5SLC18A3BCHEACHE | |
| SCHEMBL6439407 | 0.84 | SLC18A3 (0.52) | SIGMAR1CCR5SLC18A3KDM1AMAOB | |
| SCHEMBL6439405 | 0.84 | SLC18A3 (0.52) | SIGMAR1CCR5SLC18A3KDM1AMAOB | |
| SCHEMBL5040073 | 0.79 | SIGMAR1 (0.60) | SIGMAR1BCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL8479695 | 0.78 | SIGMAR1 (0.58) | SIGMAR1BCHEACHEBACE1 | |
| SCHEMBL6439494 | 0.78 | SLC18A3 (0.51) | SIGMAR1SLC18A3BCHEACHEBACE1 | |
| SCHEMBL6441170 | 0.78 | SLC18A3 (0.48) | SIGMAR1CCR5SLC18A3BCHEACHE | |
| SCHEMBL6441171 | 0.78 | SLC18A3 (0.48) | SIGMAR1CCR5SLC18A3BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360184-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ 1 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-03-30 | — | — | EP | disclosed |
| EP-1360184-A1 | PIPERIDINEE DERIVATIVES AS NEUROKININ 1 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-12 | — | — | EP | disclosed |
| US-6642226-B2 | Such as cis-(3,5-bis-trifluoromethyl-phenyl)-(4-(4-methyl-piperazin-1-yl),-3-phenyl -piperidin-1-yl)-methanone; for treatment of diseases related to neurokinin receptors | HOFFMAN-LA ROCHE INC. | 2003-11-04 | — | — | US | disclosed |
| US-20020151547-A1 | Substituted phenyl-piperidine methanone compounds | F.HOFFMANN-LA ROCHE AG (CH) | 2002-10-17 | — | — | US | disclosed |
| WO-2002062784-A1 | PIPERIDINEE DERIVATIVES AS NEUROKININ 1 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020151547-A1 | Substituted phenyl-piperidine methanone compounds | TACR1, OPRK1, TACR2 | SIGMAR1 27/4885CCR5 57/4885SLC18A3 2396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.