SCHEMBL6438872

SCHEMBL6438872

CS(=O)(=O)c1ccc(-c2[nH]nc(CO)c2C2CCCCC2)cc1

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 10/20 0.47
PTGS1 P23219 2/20 0.43
GHSR Q92847 2/20 0.39
JAK2 O60674 1/20 0.37
JAK1 P23458 1/20 0.37
TYK2 P29597 1/20 0.37
JAK3 P52333 1/20 0.37
KMT2A Q03164 1/20 0.37
BRD4 O60885 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6439748 0.89 PTGS2 (0.44) PTGS2PTGS1GHSRJAK2JAK1
SCHEMBL6442228 0.88 PTGS2 (0.44) PTGS2PTGS1GHSRBRD4
SCHEMBL6439645 0.87 PTGS2 (0.42) PTGS2PTGS1GHSRJAK2JAK1
SCHEMBL6441485 0.86 PTGS2 (0.41) PTGS2PTGS1GHSR
SCHEMBL6439597 0.85 PTGS2 (0.41) PTGS2PTGS1GHSR
SCHEMBL6438018 0.84 PTGS2 (0.43) PTGS2PTGS1GHSR
SCHEMBL6439880 0.83 PTGS2 (0.49) PTGS2PTGS1GHSR
SCHEMBL6438974 0.82 KDR (0.39) PTGS2PTGS1
SCHEMBL4958133 0.81 PTGS2 (0.44) PTGS2PTGS1GHSRKMT2ABRD4
SCHEMBL6441183 0.81 PTGS2 (0.43) PTGS2PTGS1GHSRKMT2ABRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1246621-A4 NITROSATED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2004-11-24 EP claimed
EP-1246621-A1 NITROSATED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2002-10-09 EP claimed
WO-2001045703-A1 NITROSATED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2001-06-28 WO claimed
EP-1534683-A4 CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2005-08-24 EP disclosed
EP-1534683-A2 CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2005-06-01 EP disclosed
EP-1246621-A4 NITROSATED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2004-11-24 EP disclosed
WO-2004002409-A2 CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2004-01-08 WO disclosed
EP-1246621-A1 NITROSATED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2002-10-09 EP disclosed
WO-2001045703-A1 NITROSATED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2001-06-28 WO disclosed