Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835276 | 0.96 | ADRA1A (0.49) | ADRA1AHSD11B1HSD17B2CETPMAOB | |
| SCHEMBL10969055 | 0.87 | ADRA1A (0.59) | ADRA1AHSD11B1HSD17B2KDM4EALDH1A1 | |
| SCHEMBL833885 | 0.82 | ADRA1A (0.59) | ADRA1AHSD11B1HSD17B2KDM4EALDH1A1 | |
| SCHEMBL3283307 | 0.79 | BCL2L1 (0.56) | HSD11B1HSD17B2MAOBTHRATHRB | |
| SCHEMBL6164935 | 0.76 | ADRA1A (0.46) | ADRA1AHSD11B1HSD17B2KDM4EALDH1A1 | |
| SCHEMBL6169404 | 0.75 | KDM4E (0.53) | ADRA1AHSD11B1HSD17B2KDM4EALDH1A1 | |
| SCHEMBL30465797 | 0.75 | KDM4E (0.53) | ADRA1AHSD11B1HSD17B2KDM4EALDH1A1 | |
| SCHEMBL7327510 | 0.75 | ADRA1A (0.49) | ADRA1AHSD11B1HSD17B2KDM4EALDH1A1 | |
| SCHEMBL25732435 | 0.75 | ADRA1A (0.49) | ADRA1AHSD11B1HSD17B2KDM4EALDH1A1 | |
| SCHEMBL16372577 | 0.75 | ADRA1A (0.53) | ADRA1AHSD11B1HSD17B2THRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033364-B1 | Cyano containing oxamic acids and derivatives as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6194454-B1 | ANTILIPEMIC AGENTS; ANTIDIABETIC AGENTS; DIETETICS; RHEUMATIC DISEASES; ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS; ANTIDEPRESSANTS; BONE DISORDERS | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1033364-A1 | Cyano containing oxamic acids and derivatives as thyroid receptor ligands | Pfizer Products Inc. (US) | 2000-09-06 | — | — | EP | disclosed |