Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.62 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.62 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.58 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.58 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4588367 | 0.89 | AKR1C3 (0.62) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL2323586 | 0.86 | AKR1C3 (0.69) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL23682559 | 0.82 | TDP1 (0.54) | AKR1C3AKR1C2GAAMAPTMAPK1 | |
| SCHEMBL9094091 | 0.82 | AKR1C3 (0.82) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL15667439 | 0.82 | HTT (0.69) | AKR1C3AKR1C2GAAMAPTMAPK1 | |
| SCHEMBL4055339 | 0.80 | MAPK1 (0.62) | AKR1C3AKR1C2GAAMAPTMAPK1 | |
| SCHEMBL10639862 | 0.80 | GAA (0.72) | GAAALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL11518667 | 0.80 | ALDH1A1 (0.53) | AKR1C3AKR1C2GAAMAPTMAPK1 | |
| SCHEMBL6565464 | 0.80 | ALDH1A1 (0.51) | AKR1C3AKR1C2GAAMAPTMAPK1 | |
| SCHEMBL30615696 | 0.80 | MAPT (0.64) | AKR1C3AKR1C2GAAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517897-A2 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ESTROGEN AGONISTS/ANTAGONISTS | Pfizer Products Inc. (US) | 2005-03-30 | — | — | EP | disclosed |
| US-20040002524-A1 | Benzimidazole compounds and their use as estrogen agonists/antagonists | CHESWORTH RICHARD (US) | 2004-01-01 | — | — | US | disclosed |
| WO-2004000817-A2 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ESTROGEN AGONISTS/ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002524-A1 | Benzimidazole compounds and their use as estrogen agonists/antagonists | ESR1, GPER1, ESR2 | AKR1C3 634/4885AKR1C2 789/4885AKR1B10 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.