SCHEMBL6440253

SCHEMBL6440253

[CH2]C(O)COc1ccc(Br)c(C)c1Br

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.33
MEN1 O00255 5/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
KDM4E B2RXH2 2/20 0.33
GAA P10253 2/20 0.33
CYP1A2 P05177 2/20 0.33
ATM Q13315 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
LMNA P02545 4/20 0.33
NCEH1 Q6PIU2 1/20 0.32
POLB P06746 1/20 0.31
MAPT P10636 2/20 0.31
ALDH1A1 P00352 1/20 0.31
HTT P42858 1/20 0.31
ALOX15 P16050 1/20 0.31
TP53 P04637 1/20 0.30
MAPK1 P28482 1/20 0.30
AGTR1 P30556 1/20 0.30
ADRB1 P08588 2/20 0.30
ADRB2 P07550 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7022561 0.86 MEN1 (0.32) KMT2AMEN1SMN1; SMN2GAAATM
SCHEMBL15795202 0.77 KMT2A (0.40) KMT2AMEN1SMN1; SMN2KDM4EGAA
SCHEMBL10606370 0.76 TSHR (0.39) KMT2AMEN1SMN1; SMN2KDM4EGAA
SCHEMBL6439716 0.72 THRA (0.35) KMT2AMEN1SMN1; SMN2ATMLMNA
SCHEMBL11104803 0.69 KDM4E (0.66) KMT2AMEN1SMN1; SMN2KDM4ECYP1A2
SCHEMBL8071106 0.69 NQO2 (0.43) KMT2AMEN1SMN1; SMN2KDM4EGAA
SCHEMBL11099891 0.68 KMT2A (0.50) KMT2AMEN1SMN1; SMN2KDM4EGAA
SCHEMBL20742229 0.68 CYP1A2 (0.50) KMT2AMEN1KDM4ECYP1A2LMNA
SCHEMBL20742230 0.68 CYP1A2 (0.50) KMT2AMEN1KDM4ECYP1A2LMNA
SCHEMBL11396097 0.67 GAA (0.34) KMT2AMEN1SMN1; SMN2GAAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1474719-A4 POLYMERIZATION PROCESS AND MATERIALS FOR BIOMEDICAL APPLICATIONS ZMS LLC (US) 2005-12-14 EP claimed
US-20050090612-A1 Polymerization process and materials for biomedical applications ZMS, L.L.C.; A CALIFORNIA LIMITED LIABILITY CORPORATION 2005-04-28 US claimed
EP-1474719-A1 POLYMERIZATION PROCESS AND MATERIALS FOR BIOMEDICAL APPLICATIONS ZMS, LLC (US) 2004-11-10 EP claimed
WO-2003071339-A1 POLYMERIZATION PROCESS AND MATERIALS FOR BIOMEDICAL APPLICATIONS ZMS, LLC (US) 2003-08-28 WO claimed
EP-1474719-A4 POLYMERIZATION PROCESS AND MATERIALS FOR BIOMEDICAL APPLICATIONS ZMS LLC (US) 2005-12-14 EP disclosed
US-20050090612-A1 Polymerization process and materials for biomedical applications ZMS, L.L.C.; A CALIFORNIA LIMITED LIABILITY CORPORATION 2005-04-28 US disclosed
EP-1474719-A1 POLYMERIZATION PROCESS AND MATERIALS FOR BIOMEDICAL APPLICATIONS ZMS, LLC (US) 2004-11-10 EP disclosed
WO-2003071339-A1 POLYMERIZATION PROCESS AND MATERIALS FOR BIOMEDICAL APPLICATIONS ZMS, LLC (US) 2003-08-28 WO disclosed