Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.79 |
| ▸ | PDE4A | P27815 | 2/20 | 0.79 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.79 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3551034 | 1.00 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4CHPGD | |
| Hydrochloric Acid SCHEMBL6442735 | 0.99 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CHPGD | |
| Hydrochloric Acid SCHEMBL6442741 | 0.99 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL3554997 | 0.93 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL5510164 | 0.93 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL6440046 | 0.93 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL3555816 | 0.93 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CHPGD | |
| Hydrochloric Acid SCHEMBL3555869 | 0.92 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL13658117 | 0.92 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4CHPGD | |
| Hydrochloric Acid SCHEMBL3555873 | 0.92 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4CHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936622-B2 | 6-phenylbenzonaphthyridines | ALTANA PHARMA AG (DE) | 2005-08-30 | — | — | US | disclosed |
| EP-1377574-B1 | 6-PHENYLBENZONAPHTHYRIDINES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2005-01-19 | — | — | EP | disclosed |
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | TAKEDA GMBH (DE) | 2004-05-20 | — | — | US | disclosed |
| WO-2002066476-A9 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2003-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | PDE3A, PDE4A, PDE3B | PDE4D 7/4885PDE4A 2/4885PDE4B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.