Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807431 | 0.95 | ALOX5 (0.55) | ALOX5OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL7810873 | 0.92 | ALOX5 (0.67) | ALOX5OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL24901890 | 0.85 | ADAM17 (0.49) | ALOX5ADAM17MAOBNR4A2 | |
| SCHEMBL10083334 | 0.84 | MAOB (0.57) | ADAM17KDM4EMAOBNR4A2 | |
| SCHEMBL2846350 | 0.83 | ADAM17 (0.60) | ALOX5ADAM17MAOBNR4A2 | |
| SCHEMBL4944704 | 0.82 | ADAM17 (0.49) | ALOX5ADAM17KDM4EMAOBNR4A2 | |
| SCHEMBL9264156 | 0.82 | ALOX5 (0.76) | ALOX5OPRM1 | |
| SCHEMBL7811102 | 0.81 | ALOX5 (0.58) | ALOX5OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL23163726 | 0.80 | ADAM17 (0.57) | ALOX5ADAM17MAOB | |
| SCHEMBL7810991 | 0.80 | ALOX5 (0.57) | ALOX5OPRM1OPRD1OPRK1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575495-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2003082205-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |