Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL699725 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL2594662 | 0.96 | — | — | |
| Iodide SCHEMBL395471 | 0.93 | — | — | |
| Bromide SCHEMBL21066888 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Bromide SCHEMBL26105972 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Iodide SCHEMBL15541312 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Bromide SCHEMBL394566 | 0.93 | — | — | |
| Bromide SCHEMBL596228 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Iodide SCHEMBL7580905 | 0.93 | TSHR (0.57) | TSHRTHRBDNM1ALDH1A1LMNA | |
| Bromide SCHEMBL5512941 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897176-B2 | Olefin polymerization catalyst and process for producing olefin polymer with the catalyst | MITSUI CHEMICALS, INC. (JP) | 2005-05-24 | — | — | US | disclosed |
| US-20020169072-A1 | Olefin polymerization catalyst and process for produing Olefin polymer with the catalyst | MITSUI CHEMICALS, INC. (JP) | 2002-11-14 | — | — | US | disclosed |