Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 10/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL21066888 | 1.00 | TSHR (0.57) | TSHRTHRBALDH1A1HSD17B10TP53 | |
| Bromide SCHEMBL394566 | 1.00 | — | — | |
| Bromide SCHEMBL26105972 | 1.00 | TSHR (0.57) | TSHRTHRBALDH1A1HSD17B10TP53 | |
| Bromide SCHEMBL5512941 | 1.00 | — | — | |
| Bromide SCHEMBL367414 | 0.96 | — | — | |
| Iodide SCHEMBL395471 | 0.93 | — | — | |
| Iodide SCHEMBL15541312 | 0.93 | TSHR (0.57) | TSHRTHRBALDH1A1HSD17B10DNM1 | |
| Hydrochloric Acid SCHEMBL6440729 | 0.93 | TSHR (0.57) | TSHRTHRBALDH1A1HSD17B10DNM1 | |
| Iodide SCHEMBL7580905 | 0.93 | TSHR (0.57) | TSHRTHRBALDH1A1HSD17B10DNM1 | |
| Hydrochloric Acid SCHEMBL699725 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220332870-A1 | Narrow Band Gap Conjugated Polymers Employing Cross-Conjugated Donors Useful In Electronic Devices | THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2022-10-20 | — | — | US | disclosed |
| US-11359049-B2 | Gold catalyzed polymerization reactions of unsaturated substrates | THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2022-06-14 | — | — | US | disclosed |
| US-11312819-B2 | Narrow band gap conjugated polymers employing cross-conjugated donors useful in electronic devices | THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2022-04-26 | — | — | US | disclosed |
| US-20200407489-A1 | Gold Catalyzed Polymerization Reactions of Unsaturated Substrates | THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2020-12-31 | — | — | US | disclosed |
| US-10711092-B2 | Gold catalyzed polymerization reactions of unsaturated substrates | THE UNIVERSITY OF SOUTHERN MISSISSIPPI (US) | 2020-07-14 | — | — | US | disclosed |
| EP-3504259-A2 | NARROW BAND GAP CONJUGATED POLYMERS EMPLOYING CROSS-CONJUGATED DONORS USEFUL IN ELECTRONIC DEVICES | Azoulay, Jason D. (US) | 2019-07-03 | — | — | EP | disclosed |
| US-20190194385-A1 | Narrow Band Gap Conjugated Polymers Employing Cross-Conjugated Donors Useful in Electronic Devices | THE UNIVERSITY OF SOUTHERN MISSISSIPPI | 2019-06-27 | — | — | US | disclosed |
| US-20190085119-A1 | Gold Catalyzed Polymerization Reactions of Unsaturated Substrates | THE UNIVERSITY OF SOUTHERN MISSISSIPPI | 2019-03-21 | — | — | US | disclosed |
| WO-2018039347-A2 | NARROW BAND GAP CONJUGATED POLYMERS EMPLOYING CROSS-CONJUGATED DONORS USEFUL IN ELECTRONIC DEVICES | AZOULAY JASON D (US) | 2018-03-01 | — | — | WO | disclosed |
| US-9550678-B2 | Polymeric precursors for producing graphene nanoribbons and methods for preparing them | BASF SE (DE) | 2017-01-24 | — | — | US | disclosed |
| EP-1778695-B1 | POLYMERS OF THIENO[2,3-b]THIOPHENE | MERCK PATENT GMBH (DE) | 2012-03-21 | — | — | EP | disclosed |
| US-8114316-B2 | Monomers, oligomers and polymers of thieno[2,3-b]thiophene | MERCK PATENT GMBH (DE) | 2012-02-14 | — | — | US | disclosed |
| US-7714098-B2 | Mono-, oligo- and polythieno[3,2-b]thiophenes | MERCK PATENT GMBH (DE) | 2010-05-11 | — | — | US | disclosed |
| EP-1751166-B1 | MONO-, OLIGO- AND POLYTHIENO[3,2-B]THIOPHENES | MERCK PATENT GMBH (DE) | 2009-10-28 | — | — | EP | disclosed |
| US-20090072200-A1 | MONOMERS, OLIGOMERS AND POLYMERS OF THIENO[2,3-b]THIOPHENE | FLEXENABLE TECHNOLOGY LIMITED (GB) | 2009-03-19 | — | — | US | disclosed |
| US-20070232812-A1 | Mono-, Oligo- and Polythieno [3,2-B]Thiophenes | MERCK PATENT GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| EP-1778695-A1 | MONOMERS, OLIGOMERS AND POLYMERS OF THIENO[2,3-b]THIOPHENE | Merck Patent GmbH (DE) | 2007-05-02 | — | — | EP | disclosed |
| EP-1751166-A1 | MONO-, OLIGO- AND POLYTHIENO[3,2-B]THIOPHENES | MERCK PATENT GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2006021277-A1 | MONOMERS, OLIGOMERS AND POLYMERS OF THIENO[2,3-b]THIOPHENE | MERCK PATENT GMBH (DE) | 2006-03-02 | — | — | WO | disclosed |
| WO-2005111045-A1 | MONO-, OLIGO- AND POLYTHIENO[3,2-b]THIOPHENES | MERCK PATENT GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232812-A1 | Mono-, Oligo- and Polythieno [3,2-B]Thiophenes | FHIT, FUBP3, SLCO1B3 | TSHR 1273/4885THRB 649/4885ALDH1A1 3925/4885 |
| US-20090072200-A1 | MONOMERS, OLIGOMERS AND POLYMERS OF THIENO[2,3-b]THIOPHENE | FHIT, NLRP3, RFT1 | TSHR 580/4885THRB 836/4885ALDH1A1 3514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.