Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 8/20 | 0.44 |
| ▸ | AR | P10275 | 6/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392740 | 0.76 | VDR (0.65) | VDRARHDAC3 | |
| SCHEMBL6264191 | 0.71 | VDR (0.51) | VDRAR | |
| SCHEMBL5569801 | 0.71 | VDR (0.53) | VDRARPPARGPPARAFFAR4 | |
| SCHEMBL13366760 | 0.69 | VDR (0.64) | VDRARHDAC3 | |
| SCHEMBL5566469 | 0.69 | VDR (0.51) | VDRARFFAR4 | |
| SCHEMBL4479445 | 0.69 | VDR (0.43) | VDRAR | |
| SCHEMBL12868260 | 0.66 | VDR (0.70) | VDRARTP53MAPT | |
| SCHEMBL3850645 | 0.65 | VDR (0.57) | VDRAR | |
| SCHEMBL5971618 | 0.65 | VDR (0.40) | VDRARPPARGPPARDPPARA | |
| SCHEMBL6257981 | 0.65 | MRGPRX4 (0.39) | VDRARPPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511740-A1 | PHENYL-THIOPHENE TYPE VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003101978-A1 | PHENYL-THIOPHENE TYPE VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-12-11 | — | — | WO | disclosed |