Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.76 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363135 | 0.86 | HCAR3 (0.78) | HCAR3FGFR1RAB9ANPC1KDM4E | |
| SCHEMBL31591951 | 0.83 | HCAR3 (0.53) | HCAR3FGFR1RAB9ANPC1KMT2A | |
| SCHEMBL7721164 | 0.82 | HCAR3 (0.72) | HCAR3FGFR1RAB9ANPC1KMT2A | |
| SCHEMBL1299105 | 0.80 | FGFR1 (0.60) | HCAR3FGFR1RAB9ANPC1KMT2A | |
| SCHEMBL20454191 | 0.79 | HCAR3 (0.49) | HCAR3FGFR1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL16318608 | 0.76 | FGFR1 (0.60) | HCAR3FGFR1KMT2AKDM4EALDH1A1 | |
| SCHEMBL16595805 | 0.76 | HCAR3 (0.67) | HCAR3FGFR1RAB9ANPC1KDM4E | |
| SCHEMBL16496056 | 0.76 | FGFR1 (0.56) | HCAR3FGFR1KMT2AKDM4EALDH1A1 | |
| SCHEMBL12730480 | 0.76 | HCAR3 (0.62) | HCAR3FGFR1RAB9ANPC1KMT2A | |
| SCHEMBL7031069 | 0.76 | HCAR3 (0.58) | HCAR3FGFR1RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448908-A | Compounds for the treatment of specific leukemias | 拓臻股份有限公司 | 2022-12-09 | — | — | CN | disclosed |
| EP-1499305-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | Pfizer Japan Inc. (JP) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086371-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |