Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177681 | 0.87 | HCAR3 (0.54) | HCAR3RAB9ANPC1RIPK1RIPK3 | |
| SCHEMBL6176464 | 0.87 | HCAR3 (0.54) | HCAR3RAB9ANPC1RIPK1RIPK3 | |
| SCHEMBL8363135 | 0.84 | HCAR3 (0.78) | HCAR3RAB9ANPC1KDM4EGFER | |
| SCHEMBL6441326 | 0.82 | HCAR3 (0.76) | HCAR3RAB9ANPC1KDM4EGFER | |
| SCHEMBL8360112 | 0.81 | NAMPT (0.61) | HCAR3RAB9ANPC1RIPK1RIPK3 | |
| SCHEMBL6277706 | 0.79 | RIPK1 (0.49) | HCAR3RAB9ANPC1RIPK1RIPK3 | |
| SCHEMBL6175661 | 0.79 | RIPK1 (0.49) | HCAR3RAB9ANPC1RIPK1RIPK3 | |
| SCHEMBL30483201 | 0.76 | HCAR3 (0.46) | HCAR3RAB9ANPC1RIPK1RIPK3 | |
| SCHEMBL28581278 | 0.76 | HCAR3 (0.46) | HCAR3RAB9ANPC1RIPK1RIPK3 | |
| SCHEMBL28581274 | 0.76 | HCAR3 (0.46) | HCAR3RAB9ANPC1RIPK1RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4215532-A1 | PROGRAMMED CELL NECROSIS INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CN) | 2023-07-26 | — | — | EP | disclosed |
| US-6875765-B2 | Arylsulfonamide ethers, and methods of use thereof | WARNER-LAMBERT COMPANY (US) | 2005-04-05 | — | — | US | disclosed |