Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 12/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439512 | 0.90 | ALDH1A1 (0.43) | ALDH1A1TACR1SLC6A4DPP4SLC6A9 | |
| SCHEMBL6439493 | 0.85 | TACR1 (0.41) | TACR1DPP4SLC6A9SLC6A5NOTUM | |
| SCHEMBL6440874 | 0.81 | ALDH1A1 (0.41) | ALDH1A1TACR1SLC6A4DPP4NOTUM | |
| SCHEMBL5918122 | 0.80 | HIF1A (0.47) | TACR1 | |
| SCHEMBL5800189 | 0.80 | HIF1A (0.47) | TACR1 | |
| SCHEMBL6441197 | 0.75 | NPSR1 (0.38) | TACR1DPP4SLC6A9 | |
| SCHEMBL6446760 | 0.74 | NPC1 (0.44) | TACR1 | |
| SCHEMBL6446757 | 0.74 | NPC1 (0.44) | TACR1 | |
| SCHEMBL6442273 | 0.74 | NOTUM (0.41) | TACR1DPP4SLC6A9SLC6A5NOTUM | |
| SCHEMBL7147614 | 0.74 | TACR1 (0.38) | TACR1DPP4SLC6A9SLC6A5NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360184-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ 1 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-03-30 | — | — | EP | disclosed |