Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439086 | 0.81 | TACR1 (0.44) | TACR1PRCPTRPV1 | |
| SCHEMBL6439088 | 0.81 | TACR1 (0.44) | TACR1PRCPTRPV1 | |
| SCHEMBL6442797 | 0.74 | ALDH1A1 (0.45) | TACR1DPP4SLC6A9SLC6A5NOTUM | |
| SCHEMBL6439512 | 0.73 | ALDH1A1 (0.43) | TACR1DPP4SLC6A9SLC6A5NOTUM | |
| SCHEMBL6440874 | 0.71 | ALDH1A1 (0.41) | TACR1DPP4NOTUM | |
| SCHEMBL6443905 | 0.70 | HIF1A (0.45) | TACR1TRPV1 | |
| SCHEMBL6443902 | 0.70 | HIF1A (0.45) | TACR1TRPV1 | |
| SCHEMBL8689391 | 0.70 | ADRB1 (0.47) | TACR1DPP4NOTUMTRPV1MEN1 | |
| SCHEMBL6442208 | 0.69 | RHOA (0.48) | TACR1 | |
| SCHEMBL6442205 | 0.69 | RHOA (0.48) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360184-A1 | PIPERIDINEE DERIVATIVES AS NEUROKININ 1 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002062784-A1 | PIPERIDINEE DERIVATIVES AS NEUROKININ 1 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-15 | — | — | WO | disclosed |