Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.44 |
| ▸ | MAOB | P27338 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 2/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545426 | 0.83 | KDM4E (0.59) | MAOAMAOBKDM4EMAPTNSD2 | |
| SCHEMBL14534512 | 0.80 | MAOA (0.60) | MAOAMAOBKDM4EMAPTNSD2 | |
| SCHEMBL5493085 | 0.79 | MAOA (0.72) | MAOAMAOBKDM4EMAPTNSD2 | |
| SCHEMBL6442964 | 0.78 | MAOA (0.50) | MAOAMAOBKDM4EMAPTNSD2 | |
| SCHEMBL10949994 | 0.76 | HSP90AA1 (0.56) | MAOAMAOBKDM4EMAPTNSD2 | |
| SCHEMBL10944231 | 0.76 | HSP90AA1 (0.58) | MAOAMAOBKDM4EMAPTNSD2 | |
| SCHEMBL10944622 | 0.75 | HSP90AA1 (0.56) | MAOAMAOBKDM4EMAPTNSD2 | |
| SCHEMBL4726838 | 0.74 | HSP90AA1 (0.52) | MAOAMAOBKDM4EMAPTNSD2 | |
| SCHEMBL10942299 | 0.73 | HSP90AA1 (0.54) | MAOAMAOBKDM4EMAPTNSD2 | |
| SCHEMBL10941487 | 0.73 | HSP90AA1 (0.54) | MAOAMAOBKDM4EMAPTNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907363-A4 | 8-AMINOQUINOLINES | UNIV MISSISSIPPI (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-0907363-A1 | 8-AMINOQUINOLINES | THE UNIVERSITY OF MISSISSIPPI (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997036590-A1 | 8-AMINOQUINOLINES | THE UNIVERSITY OF MISSISSIPPI (US) | 1997-10-09 | — | — | WO | disclosed |