Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383569 | 0.89 | FOLH1 (0.60) | ABCB1THRATHRBFOLH1L3MBTL1 | |
| SCHEMBL590872 | 0.87 | MCL1 (0.48) | ABCB1THRATHRBFOLH1L3MBTL1 | |
| SCHEMBL2946703 | 0.85 | MAOB (0.57) | ABCB1FOLH1L3MBTL1TDP1SMN1; SMN2 | |
| SCHEMBL4483528 | 0.84 | ABCB1 (0.48) | ABCB1THRATHRBFOLH1L3MBTL1 | |
| SCHEMBL31363007 | 0.84 | ALDH1A1 (0.53) | ABCB1FOLH1L3MBTL1TDP1RAB9A | |
| SCHEMBL382869 | 0.84 | ALDH1A1 (0.53) | ABCB1FOLH1L3MBTL1TDP1RAB9A | |
| SCHEMBL2469286 | 0.84 | MRGPRX4 (0.52) | FOLH1RAB9ASMN1; SMN2MCL1ALDH1A1 | |
| SCHEMBL646463 | 0.83 | ABCB1 (0.53) | ABCB1FOLH1L3MBTL1TDP1RAB9A | |
| SCHEMBL21327204 | 0.82 | MCL1 (0.54) | FOLH1L3MBTL1TDP1SMN1; SMN2MCL1 | |
| SCHEMBL19361431 | 0.82 | PTGES (0.52) | FOLH1MCL1PTGER1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8816070-B2 | Triazole derivative as an HSP 90 inhibitor | MERCK PATENT GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| EP-2023922-B1 | TRIAZOLE DERIVATIVES II | MERCK PATENT GMBH (DE) | 2012-07-11 | — | — | EP | disclosed |
| US-8119795-B2 | Triazole derivatives II | MERCK PATENT GMBH (DE) | 2012-02-21 | — | — | US | disclosed |
| US-20100113542-A1 | TRIAZOLE DERIVATIVE AS AN HSP 90 INHIBITOR | MERCK PATENT GESELLSCHAFT (DE) | 2010-05-06 | — | — | US | disclosed |
| US-20100022540-A1 | TRIAZOLE DERIVATIVES II | MERCK PATENT GESELLSCHAFT (DE) | 2010-01-28 | — | — | US | disclosed |
| EP-2023922-A2 | TRIAZOLE DERIVATIVES II | Merck Patent GmbH (DE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007134678-A2 | TRIAZOLE DERIVATIVES II | MERCK PATENT GMBH (DE) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022540-A1 | TRIAZOLE DERIVATIVES II | HSP90AB1, HSP90AA1, HSP90AB2P | ABCB1 44/4885THRA 1358/4885THRB 1374/4885 |
| US-20100113542-A1 | TRIAZOLE DERIVATIVE AS AN HSP 90 INHIBITOR | HSP90AB1, HSP90AB2P, HSP90AA1 | ABCB1 263/4885THRA 1478/4885THRB 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.