Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27570242 | 0.83 | MAPT (0.48) | MAPTALDH1A1KDM4EL3MBTL1ALDH1A3 | |
| SCHEMBL27643656 | 0.79 | MAPT (0.45) | MAPTALDH1A1KDM4EL3MBTL1ALDH1A3 | |
| SCHEMBL7072973 | 0.77 | — | — | |
| SCHEMBL16346007 | 0.77 | S1PR1 (0.39) | MAPTALDH1A1KDM4EL3MBTL1TSHR | |
| SCHEMBL17813143 | 0.76 | MAPT (0.50) | MAPTCRHR1 | |
| SCHEMBL30616847 | 0.74 | MAPT (0.49) | MAPTALDH1A1KDM4EL3MBTL1TSHR | |
| SCHEMBL3159375 | 0.74 | MAPT (0.49) | MAPTALDH1A1KDM4EL3MBTL1TSHR | |
| SCHEMBL2302859 | 0.73 | CHRNA1 (0.34) | MAPTALDH1A1TSHRKMT2A | |
| SCHEMBL6865041 | 0.73 | VCP (0.38) | — | |
| SCHEMBL26968200 | 0.73 | S1PR1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583742-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004060870-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | disclosed |