Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 4/20 | 0.31 |
| ▸ | MAOB | P27338 | 4/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063849 | 0.85 | KDM1A (0.33) | — | |
| SCHEMBL998053 | 0.84 | CES2 (0.42) | — | |
| SCHEMBL7072973 | 0.82 | — | — | |
| SCHEMBL4434983 | 0.79 | PARP1 (0.41) | VCPPARP1MAOAMAOBRPS6KB1 | |
| SCHEMBL1701138 | 0.79 | MDM2 (0.40) | — | |
| SCHEMBL15017386 | 0.79 | AKR1C3 (0.35) | — | |
| SCHEMBL11213329 | 0.77 | PARP1 (0.37) | VCPPARP1 | |
| SCHEMBL1701126 | 0.77 | SHBG (0.50) | — | |
| SCHEMBL26968200 | 0.77 | S1PR1 (0.33) | — | |
| SCHEMBL16346007 | 0.77 | S1PR1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381363-A1 | IMIDAZO [1,2-A]-PYRIDINE DERIVATIVES AS MGLUR5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002092086-A1 | IMIDAZO (1,2-A)-PYRIDINE DERIVATIVES AS MGLUR5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-11-21 | — | — | WO | disclosed |