Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | ALPL | P05186 | 11/20 | 0.61 |
| ▸ | CA12 | O43570 | 5/20 | 0.61 |
| ▸ | RPA1 | P27694 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MARS1 | P56192 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25438769 | 0.85 | PLA2G10 (0.48) | TP53ALPLCA12RPA1CA9 | |
| SCHEMBL645342 | 0.81 | GAA (0.67) | ALPLSMN1; SMN2HPGDS | |
| SCHEMBL726574 | 0.79 | TP53 (1.00) | TP53ALPLCA12RPA1CA9 | |
| SCHEMBL1414100 | 0.76 | ALPL (1.00) | TP53ALPLCA12RPA1CA9 | |
| SCHEMBL222852 | 0.76 | TP53 (0.74) | TP53ALPLCA12RPA1CA9 | |
| SCHEMBL645330 | 0.75 | ALPL (1.00) | TP53ALPLCA12RPA1CA9 | |
| SCHEMBL3447352 | 0.75 | ALPL (1.00) | TP53ALPLCA12RPA1CA9 | |
| Hydrochloric Acid SCHEMBL27639048 | 0.75 | TP53 (0.72) | TP53ALPLCA12RPA1CA9 | |
| SCHEMBL23803931 | 0.75 | ALPL (0.73) | TP53ALPLCA12RPA1CA9 | |
| SCHEMBL15094586 | 0.75 | ALPL (1.00) | TP53ALPLCA12RPA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095044-A1 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | Sanford-Burnham Medical Research Institute California | 2012-04-19 | — | — | US | disclosed |
| EP-2433496-A1 | Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification | Burnham Institute for Medical Research (US) | 2012-03-28 | — | — | EP | disclosed |
| US-8119693-B2 | Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-02-21 | — | — | US | disclosed |
| EP-1095204-B1 | BOREHOLE CONDUIT CUTTING APPARATUS | ROBERTSON MICHAEL C (US) | 2010-03-31 | — | — | EP | disclosed |
| EP-2164329-A2 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | The Burnham Institute for Medical Research (US) | 2010-03-24 | — | — | EP | disclosed |
| US-20090156560-A1 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2009-06-18 | — | — | US | disclosed |
| WO-2009017863-A2 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-05 | — | — | WO | disclosed |
| EP-1095204-A4 | BOREHOLE CONDUIT CUTTING APPARATUS | ROBERTSON MICHAEL C (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-1095204-A1 | BOREHOLE CONDUIT CUTTING APPARATUS | Robertson, Michael C. (US) | 2001-05-02 | — | — | EP | disclosed |
| US-6186226-B1 | Borehole conduit cutting apparatus | Robertson Intellectual Properties, LLC | 2001-02-13 | — | — | US | disclosed |
| WO-2000066876-A1 | BOREHOLE CONDUIT CUTTING APPARATUS | ROBERTSON MICHAEL C (US) | 2000-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095044-A1 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | ALPL, CNDP2, ALPI | TP53 4049/4885ALPL 1/4885CA12 200/4885 |
| US-20090156560-A1 | TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION | ALPL, CNDP2, ALPI | TP53 4049/4885ALPL 1/4885CA12 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.