Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 10/20 | 1.00 |
| ▸ | CA12 | O43570 | 5/20 | 1.00 |
| ▸ | RPA1 | P27694 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | CA9 | Q16790 | 3/20 | 0.65 |
| ▸ | MARS1 | P56192 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13539270 | 0.85 | ALPL (0.73) | ALPLCA12RPA1TP53CA9 | |
| SCHEMBL4638840 | 0.85 | ALPL (0.73) | ALPLCA12RPA1TP53HDAC3 | |
| SCHEMBL1414100 | 0.84 | ALPL (1.00) | ALPLCA12RPA1TP53CA9 | |
| SCHEMBL726574 | 0.84 | TP53 (1.00) | ALPLCA12RPA1TP53CA9 | |
| SCHEMBL28195524 | 0.83 | ALPL (0.71) | ALPLCA12RPA1TP53CA9 | |
| SCHEMBL23803931 | 0.83 | ALPL (0.73) | ALPLCA12RPA1TP53CA9 | |
| SCHEMBL15094586 | 0.83 | ALPL (1.00) | ALPLCA12RPA1TP53CA9 | |
| SCHEMBL645330 | 0.83 | ALPL (1.00) | ALPLCA12RPA1TP53CA9 | |
| SCHEMBL2566128 | 0.82 | ALPL (0.69) | ALPLCA12RPA1TP53CA9 | |
| SCHEMBL30147638 | 0.82 | CHEK1 (0.72) | ALPLCA12RPA1TP53HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228504-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-07-11 | — | — | US | disclosed |
| US-20240228504-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-07-11 | — | — | US | disclosed |
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |
| WO-2021229302-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2021-11-18 | — | — | WO | disclosed |
| US-10377719-B2 | Trypanosomes inhibitors | HOFFMANN-LA ROCHE INC. (GB) | 2019-08-13 | — | — | US | disclosed |
| EP-3380455-A1 | TRYPANOSOMES INHIBITORS | H. Hoffnabb-La Roche Ag (CH) | 2018-10-03 | — | — | EP | disclosed |
| US-20180222866-A1 | TRYPANOSOMES INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2018-08-09 | — | — | US | disclosed |
| CN-108368056-A | Trypanosome inhibitor | 豪夫迈·罗氏有限公司 | 2018-08-03 | — | — | CN | disclosed |
| WO-2017089389-A1 | TRYPANOSOMES INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-01 | — | — | WO | disclosed |
| CN-104592116-B | 1,3,5-trisubstituted pyrazole compounds, and preparation method and application thereof | 山东大学 | 2017-01-11 | — | — | CN | disclosed |
| WO-2015069011-A1 | NOVEL COMPOUND, METHOD FOR PREPARATION THEREOF, AND ANTIFUNGAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2015-05-14 | — | — | WO | disclosed |
| US-20100016313-A1 | INTESTINAL ALKALINE PHOSPHATASE MODULATORS AND USES THEREOF | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016313-A1 | INTESTINAL ALKALINE PHOSPHATASE MODULATORS AND USES THEREOF | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016313-A1 | INTESTINAL ALKALINE PHOSPHATASE MODULATORS AND USES THEREOF | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222866-A1 | TRYPANOSOMES INHIBITORS | TPI1, SDHA, SDHB | ALPL 4600/4885CA12 4516/4885RPA1 3664/4885 |
| US-20240228504-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | SLC10A1, NR1H4, SLC10A2 | ALPL 1131/4885CA12 687/4885RPA1 2427/4885 |
| US-20100016313-A1 | INTESTINAL ALKALINE PHOSPHATASE MODULATORS AND USES THEREOF | ALPI, SI, FABP2 | ALPL 5/4885CA12 1444/4885RPA1 3119/4885 |
| US-10377719-B2 | Trypanosomes inhibitors | TPI1, SDHA, SDHB | ALPL 4600/4885CA12 4516/4885RPA1 3664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.