Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443583 | 1.00 | ALDH1A1 (0.50) | ALDH1A1CYP2C19RECQLCYP3A4CYP2C9 | |
| SCHEMBL5074951 | 0.84 | CYP1A2 (0.51) | CYP2C19KMT2AMEN1TDP1MAPT | |
| SCHEMBL5685808 | 0.84 | ALDH1A1 (0.51) | ALDH1A1CYP2C19RECQLCYP3A4CYP2C9 | |
| SCHEMBL31294795 | 0.81 | ALDH1A1 (0.54) | ALDH1A1CYP2C19RECQLCYP3A4CYP2C9 | |
| SCHEMBL27887649 | 0.79 | ALDH1A1 (0.52) | ALDH1A1CYP2C19RECQLCYP3A4CYP2C9 | |
| SCHEMBL27871453 | 0.79 | ALDH1A1 (0.52) | ALDH1A1CYP2C19RECQLCYP3A4CYP2C9 | |
| SCHEMBL10569043 | 0.79 | ALDH1A1 (0.52) | ALDH1A1CYP2C19RECQLCYP3A4CYP2C9 | |
| SCHEMBL9775738 | 0.79 | ALDH1A1 (0.52) | ALDH1A1CYP2C19RECQLCYP3A4CYP2C9 | |
| SCHEMBL6690104 | 0.78 | ALDH1A1 (0.55) | ALDH1A1CYP2C19RECQLCYP3A4CYP2C9 | |
| SCHEMBL28257349 | 0.78 | ALDH1A1 (0.41) | ALDH1A1CYP2C19CYP3A4CYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325146-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE 4-HYDROXY-2-PYRROLIDINONE AND N-SUBSTITUTED 4-HYDROXY-2-PYRROLIDINONES BY ENZYMATIC HYDROXYLATION | EIDGENOESSICHE TECH HOCHSCHULE (CH) | 2005-12-14 | — | — | EP | disclosed |
| US-20040009562-A1 | Process for preparing optically active 4-hydroxy-2-pyrrolidinone and n-substituted 4-hydroxy-2-pyrrolidinones by enzymatic hydroxylation | EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH (CH) | 2004-01-15 | — | — | US | disclosed |
| EP-1325146-A2 | PROCESS FOR PREPARING OPTICALLY ACTIVE 4-HYDROXY-2-PYRROLIDINONE AND N-SUBSTITUTED 4-HYDROXY-2-PYRROLIDINONES BY ENZYMATIC HYDROXYLATION | Eidgenössiche Technische Hochschule Zürich (CH) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002031174-A2 | PROCESS FOR PREPARING OPTICALLY ACTIVE 4-HYDROXY-2-PYRROLIDINONE AND N-SUBSTITUTED 4-HYDROXY-2-PYRROLIDINONES BY ENZYMATIC HYDROXYLATION | EIDGENÖSSICHE TECHNISCHE HOCHSCHULE ZÜRICH (CH) | 2002-04-18 | — | — | WO | disclosed |
| EP-1197561-A1 | Process for preparing optically active 4-hydroxy-2-pyrrolidinone and N-substituted 4-hydroxy-2-pyrrolidinones by enzymatic hydroxylation | Eidgenössische Technische Hochschule Zürich (CH) | 2002-04-17 | — | — | EP | disclosed |