Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.45 |
| ▸ | SRC | P12931 | 6/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | FLT4 | P35916 | 3/20 | 0.44 |
| ▸ | TEK | Q02763 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5566618 | 0.85 | KDR (0.61) | KDRSRCAURKAFLT4TEK | |
| SCHEMBL5561051 | 0.78 | FLT4 (0.52) | KDRSRCAURKAFLT4TEK | |
| SCHEMBL5565932 | 0.77 | KDR (0.60) | KDRSRCAURKAFLT4TEK | |
| SCHEMBL16742195 | 0.73 | SRC (0.50) | KDRSRCAURKAFLT4PDGFRB | |
| SCHEMBL5566455 | 0.73 | EGFR (0.53) | KDRSRCEGFR | |
| SCHEMBL7885709 | 0.72 | KDR (0.53) | KDRSRCAURKAFLT4TEK | |
| SCHEMBL5561123 | 0.71 | EGFR (0.56) | KDRSRCFLT4ABCB1EGFR | |
| SCHEMBL5565947 | 0.71 | KDR (0.55) | KDRSRCAURKAFLT4TEK | |
| SCHEMBL5565918 | 0.70 | SRC (0.57) | KDRSRCAURKAFLT4TEK | |
| SCHEMBL5561384 | 0.70 | KDM1A (0.54) | KDRSRCAURKAFLT4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119567-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-04 | — | — | EP | disclosed |