Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | UGCG | Q16739 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447952 | 0.97 | PIM1 (0.50) | PIM1PIM2MKNK1HRH3HSP90AA1 | |
| SCHEMBL4768815 | 0.79 | PIM1 (0.48) | PIM1PIM2MKNK1LMNAMEN1 | |
| SCHEMBL6445501 | 0.79 | HSP90AA1 (0.41) | MKNK1HRH3HSP90AA1HSP90AB1CNR2 | |
| SCHEMBL6448061 | 0.77 | HSP90AA1 (0.44) | PIM1PIM2MKNK1HRH3HSP90AA1 | |
| SCHEMBL5559235 | 0.77 | HRH3 (0.52) | HRH3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL5558971 | 0.76 | LMNA (0.50) | PIM1PIM2CNR2LMNARECQL | |
| SCHEMBL4764679 | 0.76 | CHEK2 (0.49) | PIM1PIM2LMNAMEN1KMT2A | |
| SCHEMBL5558555 | 0.76 | KDM4E (0.51) | HRH3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5565438 | 0.74 | LMNA (0.55) | PIM1PIM2CNR2LMNARECQL | |
| SCHEMBL5564284 | 0.73 | RXFP1 (0.59) | CNR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594857-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-16 | — | — | EP | claimed |
| WO-2004069133-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI -CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | claimed |
| EP-1594857-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004069133-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI -CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | disclosed |