Bromide

Bromide

SCHEMBL6444894

Br.Cc1cccc(P(c2cccc(C)c2)c2cccc(C)c2)c1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 6/20 0.58
HTR3A known ✓ P46098 1/20 0.37
ALDH1A1 P00352 1/20 0.46
MAPK1 P28482 1/20 0.46
TDP1 Q9NUW8 2/20 0.43
CYP3A4 P08684 2/20 0.43
TP53 P04637 1/20 0.41
NPC1 O15118 1/20 0.39
CASP3 P42574 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
MAPT P10636 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
HTT P42858 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
TSHR P16473 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29415924 0.97 ACHE (0.61) ACHEALDH1A1MAPK1TDP1CYP3A4
SCHEMBL49786 0.97 ACHE (0.61) ACHEALDH1A1MAPK1TDP1CYP3A4
SCHEMBL18423870 0.94 ACHE (0.58) ACHEALDH1A1MAPK1TDP1CYP3A4
SCHEMBL8849287 0.94 ACHE (0.58) ACHEALDH1A1MAPK1TDP1CYP3A4
SCHEMBL5713327 0.94 ACHE (0.58) ACHEALDH1A1MAPK1TDP1CYP3A4
Hydrochloric Acid SCHEMBL29001481 0.94 ACHE (0.58) ACHEALDH1A1MAPK1TDP1CYP3A4
Bromide SCHEMBL8849644 0.94 ACHE (0.58) ACHEALDH1A1MAPK1TDP1CYP3A4
Hydrochloric Acid SCHEMBL4529394 0.94 ACHE (0.58) ACHEALDH1A1MAPK1TDP1CYP3A4
Iodide SCHEMBL28418605 0.94 ACHE (0.58) ACHEALDH1A1MAPK1TDP1CYP3A4
Hydrochloric Acid SCHEMBL20454597 0.92 ACHE (0.55) ACHEALDH1A1MAPK1TDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1509561-A1 POWDER COATING MATTING AGENT COMPRISING ESTER AMIDE CONDENSATION PRODUCT Grace GmbH & Co. KG (DE) 2005-03-02 EP disclosed
WO-2003102048-A1 POWDER COATING MATTING AGENT COMPRISING ESTER AMIDE CONDENSATION PRODUCT GRACE GMBH & CO. KG (DE) 2003-12-11 WO disclosed