Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.63 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 3/20 | 0.38 |
| ▸ | ARG2 | P78540 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL5062296 | 0.96 | GSR (0.61) | GSRRNPEPCPB2GNAI3GNAO1 | |
| Lysine SCHEMBL5062299 | 0.96 | GSR (0.61) | GSRRNPEPCPB2GNAI3GNAO1 | |
| Lysine SCHEMBL1281704 | 0.96 | GSR (0.61) | GSRRNPEPCPB2GNAI3GNAO1 | |
| Lysine SCHEMBL1281705 | 0.96 | GSR (0.61) | GSRRNPEPCPB2GNAI3GNAO1 | |
| Lysine SCHEMBL3213815 | 0.92 | GSR (0.77) | GSRRNPEPCPB2ARG1ARG2 | |
| Lysine SCHEMBL25283016 | 0.91 | GSR (0.61) | GSRRNPEPCPB2GNAI3GNAO1 | |
| Lysine SCHEMBL5691386 | 0.91 | GSR (0.61) | GSRRNPEPCPB2GNAI3GNAO1 | |
| Lysine SCHEMBL121844 | 0.91 | GSR (0.61) | GSRRNPEPCPB2GNAI3GNAO1 | |
| Lysine SCHEMBL3749535 | 0.91 | GSR (0.61) | GSRRNPEPCPB2GNAI3GNAO1 | |
| Lysine SCHEMBL5691382 | 0.91 | GSR (0.61) | GSRRNPEPCPB2GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040136911-A1 | Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging | UZGIRIS EGIDIJUS EDWARD (US) | 2004-07-15 | — | — | US | claimed |
| US-20010028876-A1 | Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging | GENERAL ELECTRIC COMPANY | 2001-10-11 | — | — | US | claimed |
| WO-2005087273-A2 | EXTENDED-LINEAR POLYMERIC CONTRAST AGENTS AND THEIR SYNTHESIS | GENERAL ELECTRIC COMPANY (US) | 2005-09-22 | — | — | WO | disclosed |
| US-20040170562-A1 | Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging | GENERAL ELECTRIC COMPANY | 2004-09-02 | — | — | US | disclosed |
| US-20040136911-A1 | Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging | UZGIRIS EGIDIJUS EDWARD (US) | 2004-07-15 | — | — | US | disclosed |
| US-6685915-B2 | PARAMAGENTIC CHELATE COMPOUNDS; MAGNETIC RESONANCE IMAGING CONTRAST AGENT | GENERAL ELECTRIC COMPANY | 2004-02-03 | — | — | US | disclosed |
| US-20010028876-A1 | Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging | GENERAL ELECTRIC COMPANY | 2001-10-11 | — | — | US | disclosed |