Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.77 |
| ▸ | ARG2 | P78540 | 4/20 | 0.48 |
| ▸ | ARG1 | P05089 | 3/20 | 0.48 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 5/20 | 0.43 |
| ▸ | NOS1 | P29475 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL15542572 | 0.94 | GSR (0.74) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL20366122 | 0.94 | GSR (0.74) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL10805811 | 0.94 | GSR (0.74) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL27665934 | 0.94 | GSR (0.74) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL23608088 | 0.92 | GSR (0.83) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL6444907 | 0.92 | GSR (0.63) | GSRARG2ARG1RNPEPCPB2 | |
| Lysine SCHEMBL1281705 | 0.92 | GSR (0.61) | GSRRNPEPCPB2 | |
| Lysine SCHEMBL1281704 | 0.92 | GSR (0.61) | GSRRNPEPCPB2 | |
| D-Glutamate SCHEMBL20971787 | 0.92 | GSR (0.65) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL1789785 | 0.92 | GSR (0.65) | GSRARG2ARG1RNPEPCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094116-B1 | SOLID OR AQUEOUS ALKALINE PREPARATION COMPRISING A CREATINE COMPONENT, PROCESS FOR THE PRODUCTION THEREOF AND THE USE THEREOF | ALZCHEM TROSTBERG GMBH (DE) | 2010-05-19 | — | — | EP | claimed |
| US-20100056633-A1 | SOLID OR AQUEOUS ALKALINE PREPARATION COMPRISING A CREATINE COMPONENT, PROCESS FOR THE PRODUCTION THEREOF AND THE USE THEREOF | ALZCHEM TROSTBERG GMBH (DE) | 2010-03-04 | — | — | US | claimed |
| US-6346569-B1 | DISPERSING FEED POLYSUCCINIMIDE WITH DISPERSANT, REACTING DISPERSED POLYSUCCINIMIDE WITH CROSS-LINKING AGENT | MITSUI CHEMICALS, INC. (JP) | 2002-02-12 | — | — | US | disclosed |
| US-6072024-A | Production process of cross-linked polyaspartic acid resin | MITSUI CHEMICALS, INC. (JP) | 2000-06-06 | — | — | US | disclosed |
| EP-0866084-A2 | Production process of cross-linked polyaspartic acid resin | Mitsui Chemicals, Inc. (JP) | 1998-09-23 | — | — | EP | disclosed |