Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | GPR39 | O43194 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6445919 | 0.88 | HIF1A (0.51) | APPHIF1AKDM4ECHUKALDH1A1 | |
| SCHEMBL6444686 | 0.82 | RAB9A (0.42) | APPKDM4EPIK3CDALDH1A1 | |
| SCHEMBL6443145 | 0.82 | HIF1A (0.56) | APPHIF1AKDM4EPIK3CDALDH1A1 | |
| SCHEMBL5040159 | 0.80 | ADORA2A (0.50) | APPHIF1AKDM4EALDH1A1HPGD | |
| SCHEMBL6446516 | 0.78 | METAP1 (0.48) | HIF1AKDM4EPIK3CDALDH1A1HPGD | |
| SCHEMBL6446629 | 0.77 | APP (0.47) | APPKDM4EEPHX2CHUKALDH1A1 | |
| SCHEMBL6449459 | 0.75 | APP (0.52) | APPKDM4EEPHX2CHUKALDH1A1 | |
| SCHEMBL7892769 | 0.73 | DHFR (0.39) | KDM4EPIK3CDALDH1A1HPGD | |
| SCHEMBL6443545 | 0.73 | ADORA1 (0.63) | APPCHUK | |
| SCHEMBL8043537 | 0.72 | HIF1A (0.77) | HIF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261327-B1 | ADENOSINE RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2005-04-27 | — | — | EP | disclosed |