Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19994497 | 0.84 | KDM4E (0.49) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1007145 | 0.82 | HPGD (0.55) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL12501973 | 0.80 | MEN1 (0.55) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5142596 | 0.79 | HSD17B2 (0.50) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL13373337 | 0.79 | KMT2A (0.58) | MEN1KMT2AALDH1A1HTTHPGD | |
| SCHEMBL3727867 | 0.78 | HDAC6 (0.45) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL14427603 | 0.76 | MEN1 (0.66) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL12647585 | 0.75 | CTNNB1 (0.51) | KMT2AALDH1A1HTTSMN1; SMN2HPGD | |
| SCHEMBL1801614 | 0.75 | ALDH1A1 (0.77) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL15969237 | 0.74 | CTNNB1 (0.79) | ALDH1A1HTTSMN1; SMN2HPGDCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499305-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | Pfizer Japan Inc. (JP) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086371-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |