Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142596 | 0.91 | HSD17B2 (0.50) | KDM4EKMT2APLAUHTTALDH1A1 | |
| SCHEMBL30069113 | 0.89 | RAB9A (0.62) | KDM4EKMT2APLAUHTTALDH1A1 | |
| SCHEMBL19994498 | 0.89 | RAB9A (0.62) | KDM4EKMT2APLAUHTTALDH1A1 | |
| SCHEMBL6445178 | 0.84 | MEN1 (0.54) | KDM4EKMT2AHTTALDH1A1RAB9A | |
| SCHEMBL3727867 | 0.83 | HDAC6 (0.45) | KDM4EKMT2AHTTALDH1A1RAB9A | |
| SCHEMBL19183584 | 0.81 | RAB9A (0.43) | KDM4EKMT2AHTTALDH1A1RAB9A | |
| SCHEMBL13373337 | 0.81 | KMT2A (0.58) | KMT2AHTTALDH1A1HPGDMEN1 | |
| SCHEMBL1249135 | 0.78 | KDM4E (0.49) | KDM4EKMT2APLAUHTTALDH1A1 | |
| SCHEMBL6112686 | 0.78 | KMT2A (0.41) | KDM4EKMT2AHTTALDH1A1RAB9A | |
| SCHEMBL1801614 | 0.77 | ALDH1A1 (0.77) | KDM4EKMT2AHTTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515904-A1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | Centre Leon Berard (FR) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018054989-A1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | CENTRE LEON BERARD (FR) | 2018-03-29 | — | — | WO | disclosed |