Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5998388 | 0.88 | KDR (0.34) | KDRRAPGEF4PDK1KDM4EMEN1 | |
| SCHEMBL1626098 | 0.86 | ADRB2 (0.39) | KDRRAPGEF4PDK1KDM4EMEN1 | |
| SCHEMBL1626104 | 0.84 | LMNA (0.35) | KDRRAPGEF4PDK1KDM4EMEN1 | |
| SCHEMBL1625527 | 0.84 | LMNA (0.35) | KDRRAPGEF4PDK1KDM4EMEN1 | |
| SCHEMBL1625664 | 0.84 | LMNA (0.35) | KDRRAPGEF4PDK1KDM4EMEN1 | |
| SCHEMBL7146280 | 0.83 | KDR (0.37) | KDRPDK1ALDH1A1GAAMAPT | |
| SCHEMBL27581312 | 0.80 | EPAS1 (0.53) | PDK1MEN1ALDH1A1GAAMAPT | |
| SCHEMBL1625847 | 0.78 | AR (0.36) | KDRRAPGEF4KDM4EMEN1ALDH1A1 | |
| SCHEMBL1625837 | 0.77 | TRPV1 (0.46) | KDRKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL5521825 | 0.76 | IDO1 (0.38) | KDRRAPGEF4PDK1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499305-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | Pfizer Japan Inc. (JP) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086371-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |