Fluoride

Fluoride

SCHEMBL6445648

F.O=C(O)c1cc(Cl)c(Cl)c(Cl)c1Cl

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.47
TSHR P16473 4/20 0.45
ALDH1A1 P00352 3/20 0.45
TP53 P04637 1/20 0.45
CASP1 P29466 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
AKR1C4 P17516 1/20 0.43
AKR1C3 P42330 1/20 0.43
AKR1C2 P52895 1/20 0.43
AKR1C1 Q04828 1/20 0.43
HPGD P15428 2/20 0.42
HSD17B10 Q99714 2/20 0.42
HTT P42858 2/20 0.42
KDM4E B2RXH2 2/20 0.42
MAPT P10636 2/20 0.42
MEN1 O00255 1/20 0.42
PKM P14618 1/20 0.42
KMT2A Q03164 1/20 0.42
HSP90AA1 P07900 1/20 0.42
POLB P06746 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1437003 0.98 CYP3A4 (0.48) CYP3A4TSHRALDH1A1TP53CASP1
Ethylene SCHEMBL27542624 0.93 CYP3A4 (0.45) CYP3A4TSHRALDH1A1TP53CASP1
SCHEMBL11677054 0.85 CYP3A4 (0.54) CYP3A4TSHRALDH1A1TP53CASP1
SCHEMBL8974977 0.79 KEAP1 (0.53) CYP3A4TSHRALDH1A1TP53CASP1
SCHEMBL2891876 0.79 AKR1C2 (0.57) TSHRALDH1A1TP53CASP1SMN1; SMN2
SCHEMBL3136996 0.79 TSHR (0.43) CYP3A4TSHRALDH1A1TP53CASP1
SCHEMBL543424 0.79 CYP3A4 (0.45) CYP3A4TSHRALDH1A1TP53CASP1
SCHEMBL30632048 0.79 AKR1C2 (0.57) TSHRALDH1A1TP53CASP1SMN1; SMN2
SCHEMBL14273026 0.79 AKR1C2 (0.57) CYP3A4TSHRALDH1A1TP53CASP1
SCHEMBL1315659 0.78 CYP3A4 (0.48) CYP3A4TSHRALDH1A1TP53CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1233010-B1 Method for production of organic fluorine compound NIPPON CATALYTIC CHEM IND (JP) 2005-06-15 EP disclosed
EP-0899256-B1 Method for production of organic fluorine compound NIPPON CATALYTIC CHEM IND (JP) 2003-08-06 EP disclosed
EP-1233010-A1 Method for production of organic fluorine compound Nippon Shokubai Co., Ltd. (JP) 2002-08-21 EP disclosed
US-6392084-B1 FLUORINATION OF AN ORGANO(BROMINE OR CHLORIDE) COMPOUND IN BENZONITRILE SOLVENT NIPPON SHOKUBAI CO., LTD. (JP) 2002-05-21 US disclosed
EP-0899256-A2 Method for production of organic fluorine compound NIPPON SHOKUBAI CO., LTD. (JP) 1999-03-03 EP disclosed