SCHEMBL6445950

SCHEMBL6445950

CC1=C2c3c(cc(C)n3-c3ccccc3)C1[Si]2(C)C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.36
NOTUM Q6P988 1/20 0.36
SMN1; SMN2 Q16637 4/20 0.34
RAB9A P51151 3/20 0.34
TP53 P04637 2/20 0.34
NPC1 O15118 2/20 0.34
TSHR P16473 2/20 0.34
MEN1 O00255 5/20 0.33
KMT2A Q03164 5/20 0.33
MAPT P10636 3/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
POLB P06746 1/20 0.33
RECQL P46063 1/20 0.33
LMNA P02545 3/20 0.32
CYP1A2 P05177 2/20 0.32
CYP2C19 P33261 2/20 0.32
CYP2C9 P11712 1/20 0.32
MAPK1 P28482 2/20 0.32
HTT P42858 2/20 0.32
MITF O75030 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6462859 0.80 CNR1 (0.31) CNR2
Hydrochloric Acid SCHEMBL5948716 0.79
Hydrochloric Acid SCHEMBL6702848 0.76
SCHEMBL6448188 0.76 SMN1; SMN2 (0.40) ALDH1A1NOTUMSMN1; SMN2RAB9ATP53
Hydrochloric Acid SCHEMBL6066107 0.74
Hydrochloric Acid SCHEMBL6064966 0.74
SCHEMBL6443427 0.68
SCHEMBL6463100 0.67 NPC1 (0.31) SMN1; SMN2RAB9ATP53NPC1TSHR
SCHEMBL17589460 0.64 ALDH1A1 (0.44) ALDH1A1NOTUMSMN1; SMN2RAB9ATP53
SCHEMBL10205955 0.61 ALDH1A1 (0.43) ALDH1A1NOTUMSMN1; SMN2RAB9ATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1053263-B1 CATALYST SYSTEM BASELL POLYOLEFINE GMBH (DE) 2003-10-01 EP claimed
US-6949614-B1 Catalyst system BASELL POLYOLEFINE GMBH (DE) 2005-09-27 US disclosed
EP-1272532-B1 SALINE CHEMICAL COMPOSITION, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF IN CATALYST SYSTEMS FOR PRODUCING POLYOLEFINS BASELL POLYOLEFINE GMBH (DE) 2005-05-04 EP disclosed
EP-1054914-B1 ZWITTERIONIC, NEUTRAL TRANSITION METAL COMPOUND BASELL POLYOLEFINE GMBH (DE) 2004-03-03 EP disclosed
EP-1175262-B1 CATALYST SYSTEM BASELL POLYOLEFINE GMBH (DE) 2004-02-18 EP disclosed
EP-1290002-B1 CHEMICAL PRODUCTS SUITED FOR USE AS CO-CATALYSTS, METHOD FOR THE PREPARATION THEREOF AND THEIR USE IN CATALYST SYSTEMS FOR PRODUCING POLYOLEFINS BASELL POLYOLEFINE GMBH (DE) 2004-01-21 EP disclosed