Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 4/20 | 0.76 |
| ▸ | CTSL | P07711 | 2/20 | 0.56 |
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | REN | P00797 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 3/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | ECE1 | P42892 | 2/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.53 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.52 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.52 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.52 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.52 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9232828 | 1.00 | CTSD (0.76) | CTSDCTSLCTSSTRPM8CA2 | |
| SCHEMBL6446780 | 1.00 | CTSD (0.76) | CTSDCTSLCTSSTRPM8CA2 | |
| SCHEMBL9740721 | 1.00 | CTSD (0.76) | CTSDCTSLCTSSTRPM8CA2 | |
| SCHEMBL6445103 | 1.00 | CTSD (0.76) | CTSDCTSLCTSSTRPM8CA2 | |
| SCHEMBL6132144 | 0.98 | CTSD (0.76) | CTSDCTSLCTSSTRPM8CA2 | |
| SCHEMBL6449641 | 0.98 | CTSD (0.76) | CTSDCTSLCTSSTRPM8CA2 | |
| Acetic Acid SCHEMBL7270658 | 0.95 | CTSD (0.73) | CTSDCTSLCTSSTRPM8CA2 | |
| SCHEMBL6454320 | 0.93 | CTSD (0.68) | CTSDCTSLCTSSTRPM8CA2 | |
| SCHEMBL7342149 | 0.93 | CTSD (0.68) | CTSDCTSLCTSSTRPM8CA2 | |
| SCHEMBL6448985 | 0.93 | CTSD (0.68) | CTSDCTSLCTSSTRPM8CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | claimed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | claimed |
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0839798-A3 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0402646-B1 | Retroviral protease inhibiting compounds | ABBOTT LAB (US) | 1998-07-22 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |