Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 5/20 | 0.68 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 1/20 | 0.50 |
| ▸ | ECE1 | P42892 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.48 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.48 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.48 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.48 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.48 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.48 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.48 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448595 | 0.97 | CTSD (0.69) | CTSDCA2TRPM8CA5ACTSL | |
| SCHEMBL6446151 | 0.93 | CTSD (0.76) | CTSDCA2TRPM8CA5ACTSL | |
| SCHEMBL6445103 | 0.93 | CTSD (0.76) | CTSDCA2TRPM8CA5ACTSL | |
| SCHEMBL9740721 | 0.93 | CTSD (0.76) | CTSDCA2TRPM8CA5ACTSL | |
| SCHEMBL9232828 | 0.93 | CTSD (0.76) | CTSDCA2TRPM8CA5ACTSL | |
| SCHEMBL6446780 | 0.93 | CTSD (0.76) | CTSDCA2TRPM8CA5ACTSL | |
| SCHEMBL6132144 | 0.91 | CTSD (0.76) | CTSDCA2TRPM8CA5ACTSL | |
| SCHEMBL6449641 | 0.91 | CTSD (0.76) | CTSDCA2TRPM8CA5ACTSL | |
| SCHEMBL6447685 | 0.91 | CTSD (0.57) | CTSDCA2CTSLREN | |
| SCHEMBL7270703 | 0.89 | CTSD (0.68) | CTSDCA2TRPM8CA5ACTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997459-A1 | Intermediates for preparing retroviral protease inhibiting compounds | Abbott Laboratories (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5837873-A | PROTECTED OXYDIAMINES | ABBOTT LABORATORIES (US) | 1998-11-17 | — | — | US | disclosed |
| US-5648497-A | Retroviral protease inhibiting compounds | ABBOTT LABORAOTRIES (US) | 1997-07-15 | — | — | US | disclosed |
| US-5616714-A | PYRIDYL, THIAZOLYL-SUBSTITUTED AMINO ACID DERIVATIVES | ABBOTT LABORATORIES (US) | 1997-04-01 | — | — | US | disclosed |
| US-5597926-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| US-5554783-A | (2R, 3R, 4S, 5S)-3-ACETOXY-2,5-BIS/BENZYLOXYCARBONYLAMINO/ -4-BROMO-1,5-DIPHENYLHEXANE | ABBOTT LABORATORIES (US) | 1996-09-10 | — | — | US | disclosed |
| US-5541334-A | TREATING HIV | ABBOTT LABORATORIES (US) | 1996-07-30 | — | — | US | disclosed |
| US-5354866-A | Treating HIV infections | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| EP-0486948-A2 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1992-05-27 | — | — | EP | disclosed |