Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRA | P18433 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6449495 | 0.80 | CA2 (0.66) | CA2ALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6449490 | 0.80 | CA2 (0.66) | CA2ALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6449485 | 0.80 | CA2 (0.66) | CA2ALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL12313339 | 0.79 | NTRK1 (0.51) | CA2KDM4EALDH1A1NTRK1TRPM8 | |
| SCHEMBL14753660 | 0.78 | NPC1 (0.49) | CA2KDM4EALDH1A1NTRK1TRPM8 | |
| SCHEMBL6204342 | 0.76 | KDM4E (0.52) | PTPRACA2KDM4EALDH1A1KCNA5 | |
| SCHEMBL6447880 | 0.75 | NTRK1 (0.47) | CA2KDM4EALDH1A1NTRK1TRPM8 | |
| SCHEMBL17792943 | 0.75 | SLC1A5 (0.42) | PTPRACA2KDM4EALDH1A1NTRK1 | |
| SCHEMBL7322799 | 0.74 | NPC1 (0.53) | PTPRAKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL7280361 | 0.74 | NPC1 (0.53) | PTPRAKDM4EALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |