SCHEMBL6446546

SCHEMBL6446546

O=C(O)c1ccc(CN2C(=O)c3cc(C#CCc4ccccc4)ccc3OS2(=O)=O)cc1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 8/20 0.49
SLC22A8 Q8TCC7 1/20 0.48
MEN1 O00255 1/20 0.38
HPGD P15428 1/20 0.38
KMT2A Q03164 1/20 0.38
FFAR1 O14842 1/20 0.37
FFAR4 Q5NUL3 1/20 0.37
HDAC1 Q13547 4/20 0.37
HDAC2 Q92769 4/20 0.37
CA12 O43570 2/20 0.36
CA9 Q16790 2/20 0.36
CA2 P00918 1/20 0.36
ENPP2 Q13822 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6240857 0.79 MMP13 (0.50) MMP13SLC22A8MEN1HPGDKMT2A
SCHEMBL6454497 0.79 MMP13 (0.50) MMP13SLC22A8MEN1HPGDKMT2A
SCHEMBL6767426 0.77 KMT2A (0.67) MMP13SLC22A8MEN1HPGDKMT2A
SCHEMBL6477654 0.77 MMP13 (0.52) MMP13SLC22A8HDAC1HDAC2CA12
SCHEMBL6256775 0.72 MMP13 (0.42) MMP13SLC22A8HPGDENPP2
SCHEMBL8355360 0.72 MMP13 (0.52) MMP13SLC22A8FFAR1FFAR4HDAC1
SCHEMBL6449268 0.71 MMP13 (0.51) MMP13SLC22A8MEN1HPGDKMT2A
SCHEMBL6450511 0.70 MMP13 (0.48) MMP13SLC22A8MEN1HPGDKMT2A
SCHEMBL6448095 0.69 FFAR1 (0.44) MMP13SLC22A8FFAR1FFAR4HDAC1
SCHEMBL6489891 0.69 MMP13 (0.43) MMP13SLC22A8MEN1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1536786-A1 COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2005-06-08 EP disclosed
EP-1434585-A1 ALKYNE MATRIX METALLOPROTEINASE INHIBITORS Warner-Lambert Company LLC (US) 2004-07-07 EP disclosed
WO-2004006913-A1 COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
WO-2003032999-A1 ALKYNE MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2003-04-24 WO disclosed