Sugi Predict

Sugi Predict / Compounds / SCHEMBL644769

SCHEMBL644769

SCHEMBL644769

O=C(O)c1nccc(F)c1F

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 8/20 0.68
▸ ASPH Q12797 4/20 0.68
▸ KDM8 Q8N371 4/20 0.68
▸ MAPT P10636 4/20 0.45
▸ ALDH1A1 P00352 4/20 0.45
▸ CYP3A4 P08684 1/20 0.45
▸ ALOX15 P16050 1/20 0.45
▸ TSHR P16473 1/20 0.45
▸ BLM P54132 1/20 0.45
▸ AGER Q15109 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ CYP1A2 P05177 1/20 0.40
▸ NAPRT Q6XQN6 1/20 0.39
▸ KMO O15229 5/20 0.39
▸ MYC P01106 1/20 0.37
▸ KDM6B O15054 1/20 0.36
▸ TET3 O43151 1/20 0.36
▸ KDM4A O75164 1/20 0.36
▸ BBOX1 O75936 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10373429 0.85 KDM4E (0.60) KDM4EASPHKDM8MAPTALDH1A1
SCHEMBL15555561 0.83 KDM4E (0.47) KDM4EASPHKDM8MAPTALDH1A1
SCHEMBL28048186 0.81 KDM4E (0.55) KDM4EASPHKDM8MAPTALDH1A1
SCHEMBL2696087 0.81 KDM4E (0.46) KDM4EASPHKDM8MAPTL3MBTL1
SCHEMBL15060252 0.79 KDM4E (0.63) KDM4EASPHKDM8MAPTALDH1A1
SCHEMBL28177119 0.79 KDM4E (0.53) KDM4EASPHKDM8MAPTALDH1A1
SCHEMBL28380748 0.79 KDM4E (0.63) KDM4EASPHKDM8MAPTALDH1A1
SCHEMBL30990531 0.79 KDM4E (0.63) KDM4EASPHKDM8MAPTALDH1A1
SCHEMBL28478885 0.79 KDM4E (0.53) KDM4EASPHKDM8MAPTALDH1A1
SCHEMBL28337894 0.79 KDM4E (0.58) KDM4EASPHKDM8MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119874611-A Process for preparing benzyl 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) picolinate 科迪华农业科技有限责任公司 2025-04-25 — — CN disclosed
CN-112105264-B Polymeric dispersants for pesticides 禾大国际股份公开有限公司 2022-08-26 — — CN disclosed
WO-2021147974-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2021-07-29 — — WO disclosed
CN-112105264-A Polymeric dispersants for pesticides 禾大国际股份公开有限公司 2020-12-18 — — CN disclosed
EP-3555049-A1 METHOD OF PREPARING BENZY 4-AMINO-3-CHLORO-5-FLUORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PICOLINATE Dow AgroSciences LLC (US) 2019-10-23 — — EP disclosed
US-10407391-B2 Method of preparing benzyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate DOW AGROSCIENCES LLC (US) 2019-09-10 — — US disclosed
EP-3356362-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED BICYCLIC HETEROCYCLIC DERIVATIVES AS PEST CONTROL AGENTS Bayer CropScience Aktiengesellschaft (DE) 2018-08-08 — — EP disclosed
WO-2018111639-A1 METHOD OF PREPARING BENZY 4-AMINO-3-CHLORO-5-FLUORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PICOLINATE DOW AGROSCIENCES LLC (US) 2018-06-21 — — WO disclosed
US-20180162814-A1 METHOD OF PREPARING BENZYL 4-AMINO-3-CHLORO-5-FLUORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PICOLINATE DOW AGROSCIENCES LLC (US) 2018-06-14 — — US disclosed
EP-2463283-B1 Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases PFIZER PROD INC (US) 2014-06-11 — — EP disclosed
EP-2010520-B1 HETEROBICYCLIC AMIDES FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES PFIZER PROD INC (US) 2012-09-12 — — EP disclosed
EP-2463283-A1 Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases Pfizer Products Inc. (US) 2012-06-13 — — EP disclosed
US-8119624-B2 Fused phenyl amido heterocyclic compounds PFIZER INC. (US) 2012-02-21 — — US disclosed
US-20110039821-A1 Fused Phenyl Amido Heterocyclic Compounds PFIZER INC 2011-02-17 — — US disclosed
US-7842713-B2 Fused phenyl amido heterocyclic compounds PFIZER INC (US) 2010-11-30 — — US disclosed
WO-2010135579-A1 FLUORINATED DIARYL UREA DERIVATIVES CONCERT PHARMACEUTICALS, INC. (US) 2010-11-25 — — WO disclosed
EP-2010520-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES Pfizer Products Incorporated (US) 2009-01-07 — — EP disclosed
US-20080280875-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS PFIZER INC. 2008-11-13 — — US disclosed
WO-2007122482-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES PFIZER PRODUCTS INC. (US) 2007-11-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110039821-A1 Fused Phenyl Amido Heterocyclic Compounds GCK, GCKR, HK1 KDM4E 1790/4885ASPH 1652/4885KDM8 1525/4885
US-10407391-B2 Method of preparing benzyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate CYP4F2, CYP4F3, CYP2F1 KDM4E 1568/4885ASPH 381/4885KDM8 3176/4885
US-20180162814-A1 METHOD OF PREPARING BENZYL 4-AMINO-3-CHLORO-5-FLUORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PICOLINATE CYP4F2, CYP4F3, CYP2F1 KDM4E 1568/4885ASPH 381/4885KDM8 3176/4885
US-20080280875-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS GCK, GCKR, HK1 KDM4E 1790/4885ASPH 1652/4885KDM8 1525/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.