Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ASPH | Q12797 | 1/20 | 0.46 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 2/20 | 0.34 |
| ▸ | CES1 | P23141 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL2588636 | 0.93 | KDM4E (0.41) | KDM4EASPHKDM8OPRM1IDO1 | |
| SCHEMBL15555561 | 0.81 | KDM4E (0.47) | KDM4EASPHKDM8MAPTCES2 | |
| SCHEMBL644769 | 0.81 | KDM4E (0.68) | KDM4EASPHKDM8MAPTCES2 | |
| SCHEMBL28299885 | 0.80 | KDM4E (0.43) | KDM4EASPHKDM8OPRM1IDO1 | |
| SCHEMBL28098526 | 0.79 | KDM4E (0.37) | KDM4EASPHKDM8 | |
| Hydrochloric Acid SCHEMBL20599691 | 0.78 | KDM4E (0.36) | KDM4EASPHKDM8 | |
| SCHEMBL17785403 | 0.76 | IKBKB (0.46) | KDM4EASPHKDM8OPRM1HTT | |
| SCHEMBL319270 | 0.75 | MAPT (0.49) | KDM4EMAPTHTTL3MBTL1MKNK1 | |
| SCHEMBL32683865 | 0.74 | OPRM1 (0.43) | KDM4EASPHKDM8OPRM1IDO1 | |
| Hydrochloric Acid SCHEMBL18694922 | 0.73 | MAPT (0.47) | KDM4EMAPTHTTL3MBTL1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120107240-A1 | Probes and methods of melanoma imaging | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-05-03 | — | — | US | claimed |
| US-11173145-B2 | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-11-16 | — | — | US | disclosed |
| EP-3600312-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183145-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-10-04 | — | — | WO | disclosed |
| US-20150023877-A1 | METHODS OF PARKINSONS DISEASE DIAGNOSIS AND MONITORING TREATMENT | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2015-01-22 | — | — | US | disclosed |
| US-20120107240-A1 | Probes and methods of melanoma imaging | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120107240-A1 | Probes and methods of melanoma imaging | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-05-03 | — | — | US | disclosed |
| WO-2010013794-A1 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150023877-A1 | METHODS OF PARKINSONS DISEASE DIAGNOSIS AND MONITORING TREATMENT | PARK7, SNCA, COMT | KDM4E 3989/4885ASPH 2607/4885KDM8 4342/4885 |
| US-20120107240-A1 | Probes and methods of melanoma imaging | TYR, MC1R, MCHR1 | KDM4E 3244/4885ASPH 1658/4885KDM8 3283/4885 |
| US-11173145-B2 | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase | TPH2, TPH1, IDO2 | KDM4E 1127/4885ASPH 273/4885KDM8 447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.