Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 8/20 | 0.43 |
| ▸ | MEP1A | Q16819 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2774179 | 0.83 | SIGMAR1 (0.43) | MEP1BMEP1APRSS1PRSS2PRSS3 | |
| SCHEMBL7087183 | 0.83 | MEN1 (0.54) | MEP1BMEP1AHDAC1MEN1KMT2A | |
| SCHEMBL5956199 | 0.81 | KAT6A (0.42) | MEP1BHDAC1PRSS1LOXL2PRSS2 | |
| SCHEMBL2775292 | 0.80 | HDAC6 (0.48) | MEP1BMEP1ATSHR | |
| SCHEMBL409611 | 0.80 | MEP1B (0.47) | MEP1BMEP1AALDH1A1TSHRPRSS1 | |
| SCHEMBL410445 | 0.79 | KDM4E (0.37) | MEP1BMEP1APRSS1PRSS2PRSS3 | |
| SCHEMBL320097 | 0.79 | PRSS1 (0.61) | MEP1BMEP1ATSHRF10HDAC1 | |
| SCHEMBL6334369 | 0.79 | HRH3 (0.48) | NOS1MEP1BALDH1A1TSHRHDAC1 | |
| SCHEMBL7087160 | 0.78 | MEP1B (0.53) | MEP1BMEP1AHDAC1MEN1KMT2A | |
| SCHEMBL7083688 | 0.78 | PPARG (0.52) | MEP1BMEP1AHDAC1KMT2AGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423120-A4 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORP (US) | 2005-12-28 | — | — | EP | disclosed |
| CN-1568187-A | 2H-2,3-dinitrogen phenodiazine-1-ketone and using method thereof | ICOS CORP (US) | 2005-01-19 | — | — | CN | disclosed |
| EP-1423120-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003015785-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2003-02-27 | — | — | WO | disclosed |