SCHEMBL6449186

SCHEMBL6449186

C=CCc1cc(C)cc(Cc2cc(C)cc(CC=C)c2O)c1O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AMY1A P0DUB6 1/20 0.53
CYP2C9 P11712 2/20 0.52
CYP2C19 P33261 2/20 0.52
HIF1A Q16665 2/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
GAA P10253 1/20 0.49
HSPA5 P11021 1/20 0.48
CYP2D6 P10635 1/20 0.42
HSD17B10 Q99714 1/20 0.42
GABRA1 P14867 2/20 0.41
GABRB2 P47870 2/20 0.41
KDM4E B2RXH2 1/20 0.41
ESR1 P03372 1/20 0.40
ESR2 Q92731 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
ALOX5 P09917 1/20 0.39
PTGS1 P23219 1/20 0.39
PTGS2 P35354 1/20 0.39
DHFR P00374 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9332613 0.94 GAA (0.53) AMY1ACYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL331989 0.84 GAA (0.53) AMY1AGAAHSPA5GABRA1GABRB2
SCHEMBL10356525 0.83 DHFR (0.51) AMY1ACYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL15758050 0.81 GAA (0.43) AMY1AGAAHSPA5GABRA1GABRB2
SCHEMBL4219327 0.81 GAA (0.43) GAAHSD17B10GABRA1GABRB2KDM4E
SCHEMBL5462999 0.78 HSPA5 (0.66) CYP2C9CYP2C19HIF1ASMN1; SMN2GAA
SCHEMBL333788 0.78 MEN1 (0.50) GAAGABRA1GABRB2KDM4EMEN1
SCHEMBL5882352 0.78 ERN1 (0.60) GAAGABRA1GABRB2KDM4EESR1
SCHEMBL9489328 0.77 DHFR (0.48) GAAGABRA1GABRB2KDM4EMEN1
SCHEMBL9945781 0.77 SHBG (0.51) GAAGABRA1GABRB2KDM4EESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1311604-B1 ANTIOXIDANT AGENT BASED ON PHENOLIC SALTS LANXESS DEUTSCHLAND GMBH (DE) 2005-11-02 EP disclosed
EP-1311604-A1 ANTIOXIDANT AGENT BASED ON PHENOLIC SALTS Bayer Aktiengesellschaft (DE) 2003-05-21 EP disclosed
WO-2002014419-A1 ANTIOXIDANT AGENT BASED ON PHENOLIC SALTS BAYER AKTIENGESELLSCHAFT (DE) 2002-02-21 WO disclosed