SCHEMBL6449378

SCHEMBL6449378

C=CC(=O)OC(F)(F)c1c(F)c(F)c(Oc2c(F)c(F)c(F)c(F)c2F)c(F)c1F

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21490295 0.91 SMN1; SMN2 (0.31) TSHRSMN1; SMN2
SCHEMBL6435576 0.78 TSHR (0.41) TSHRSMN1; SMN2
SCHEMBL8736667 0.74
SCHEMBL6435687 0.71
SCHEMBL13662146 0.70 SMN1; SMN2 (0.47) TSHRSMN1; SMN2
SCHEMBL6437025 0.68
SCHEMBL6468450 0.68
SCHEMBL6435068 0.68
SCHEMBL225748 0.68 THRB (0.40) TSHRSMN1; SMN2
SCHEMBL6433544 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1009729-B1 HALOGENATED ACRYLATES AND POLYMERS DERIVED THEREFROM MINNESOTA MINING & MFG (US) 2005-01-19 EP disclosed
US-6362379-B2 ACRYLATES HAVING HIGH DEGREE OF HALOGENATION AND POLYMERS USING THESE MONOMERS; USEFUL FOR OPTICAL WAVEGUIDES AND TELECOMMUNICATION 3M INNOVATIVE PROPERTIES COMPANY 2002-03-26 US disclosed
US-6313245-B1 USED IN OPTICAL DEVICES INCLUDING OPTICAL WAVEGUIDES AND INTERCONNECTING DEVICES 3M INNOVATIVE PROPERTIES COMPANY 2001-11-06 US disclosed
US-20010037028-A1 Halogenated acrylates and polymers derived therefrom 3M INNOVATIVE PROPERTIES COMPANY 2001-11-01 US disclosed
US-6288266-B1 HALOGENATED ACRYLATES OR THIOACRYLATES FOR POLYMERS 3M INNOVATIVE PROPERTIES COMPANY 2001-09-11 US disclosed
EP-1009729-A1 HALOGENATED ACRYLATES AND POLYMERS DERIVED THEREFROM MINNESOTA MINING AND MANUFACTURING COMPANY (US) 2000-06-21 EP disclosed
US-6005137-A POLYMERS USED IN OPTICAL DEVICES INCLUDING OPTICAL WAVEGUIDES AND INTERCONNECTING DEVICES 3M INNOVATIVE PROPERTIES COMPANY (US) 1999-12-21 US disclosed
WO-1998056749-A1 HALOGENATED ACRYLATES AND POLYMERS DERIVED THEREFROM MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-12-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010037028-A1 Halogenated acrylates and polymers derived therefrom ZYX, ACR, ORMDL3 TSHR 1965/4885SMN1; SMN2 4504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.