Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | STK17B | O94768 | 2/20 | 0.48 |
| ▸ | DAPK1 | P53355 | 2/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.48 |
| ▸ | DAPK2 | Q9UIK4 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070728 | 0.82 | KDM4E (0.57) | P2RY12KDM4ELMNAALDH1A1HPGD | |
| SCHEMBL19308465 | 0.78 | P2RY12 (0.73) | P2RY12KDM4ELMNAALDH1A1HPGD | |
| Bromide SCHEMBL8101087 | 0.74 | HTR1B (0.45) | P2RY12LMNAALDH1A1 | |
| SCHEMBL12136709 | 0.74 | MAPT (0.65) | P2RY12KDM4ELMNAALDH1A1HPGD | |
| Bromide SCHEMBL8100818 | 0.73 | RORC (0.43) | P2RY12LMNAALDH1A1TERT | |
| SCHEMBL7407473 | 0.72 | HTR1F (0.65) | P2RY12LMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL18328447 | 0.72 | MAPT (0.56) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL3777911 | 0.72 | SMN1; SMN2 (0.68) | P2RY12KDM4ELMNAALDH1A1MAPT | |
| SCHEMBL3867110 | 0.71 | MAPT (0.55) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL6070716 | 0.71 | MAPK10 (0.61) | P2RY12KDM4ELMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599202-A1 | TETRACYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004071507-A1 | TETRACYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2004-08-26 | — | — | WO | disclosed |